This article reports a study of the pharmacological value of mushrooms, their biologically active substances, and research trends, with a focus on species found in the Guba district of Azerbaijan. The research was conducted based on both herbarium specimens from previous years and fungal specimens collected by the authors in recent years. As a result, out of a total of 104 species and one variation recorded in the studied territory 27 have valuable therapeutic effects. Mushrooms belong to the phyla Ascomycota and Basidiomycota and are represented by 16 families, 7 orders and 22 genera.