The antioxidant properties of licorice extract were studied on the leaves of common wheat (Triticum aestivum L.) seedlings exposed to toxic concentrations of Zn²⁺ in order to create an increased content of reactive oxygen molecules in the cell and chloroplasts. Based on changes in the characteristics of recombination of millisecond delayed fluorescence of chlorophyll a (ms DF Chl a) and the pigment pool, blocking of electron transfer reactions into the electron transport chain of photosystem II, to a greater extent, on its donor side, and suppression of the accumulation of photosynthetic pigments were shown. The highest resistance of Chl a 680 to this stress was shown. During the incubation of stressed seedlings in Glycyrrhiza glabra L. extract, restorati on of electron transfer (P680*–Q_A-Q_B) in the photosystem II chain and the absorption spectra of light harvesting antenna pigments was observed. The antioxidant activity of the extract was confirmed by the reaction of the stable DPPH radical. The pharmacological effect of the bioactive composition “Glysotrical” based on the extract of Glycyrrhiza was expressed in the regeneration of the skin of rabbits in case of chemical and thermal damage. Our results suggest that the protective effect of the Glycyrrhiza Tourn. ex. L. extract is due to its rich phytochemical composition, the main components of which are flavonoids and triterpene saponins, which prevent the development of a free radical state that protects the cell from damage. Possibly, being membrane-active compounds, saponins correct the lipid component of the damaged membrane.